Therapeutic targets and biological mechanisms of curcumol on atherosclerosis: A study based on network pharmacology approach and biological studies

Background: Atherosclerosis is an extremely predominant condition. The morbidity and mortality of cardiovascular cerebrovascular ailments caused by atherosclerosis have augmented significantly in recent years. discovery research new drugs are therefore obligatory will be cooperative the clinical treatment management atherosclerosis. Objective: Curcumol extracted from traditional Chinese medicine (TCM) E-Zhu (Curcumae Rhizoma), one chief bioactive ingredients Curcuma oil (a marketed drug China). Materials Methods: To classify core targets discover main biological mechanisms curcumol against atherosclerosis, a network pharmacology tactic was commenced for data mining, experiments were engaged validation. Results: Absorption, metabolism excretion screening using TCM Systems Pharmacology Database Analysis Platform server, target forecast public databases, protein-protein interaction analysis STRING database Kyoto Encyclopedia Genes Genomes pathway to examine potential on On basis 10 related pathways recognized. Furthermore, key signaling pathways, interleukin 6 (IL-6), IL-10, JAK2/STAT3, authenticated studies. Conclusion: could improve reducing formation foam cells; mechanism action ascribed downregulation IL-6 expression, upregulation IL-10 expression inhibition JAK-STAT pathway. Therefore, this study further roles